Anti Cancer Drugs Oncology Drugs

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• Generic for Rheumatrex (Methotrexate) is used to treat certain types of cancer such as breast cancer, lung cancer, neck cancer, and skin cancer. Methotrexate is also used to treat severe psoriasis and rheumatoid arthritis. This medication works by interfering with the growth of certain cells of the body, as well as by suppressing the immune system.
• Recommended Dosage - Discount Prescription Drug Generic for Rheumatrex: The dosage of Generic for Rheumatrex prescribed to each patient will vary. Always follow your physician’s instructions and/or the directions on the prescription drug label.
• Drink plenty of fluids while taking Generic for Rheumatrex tablets.
• Missed Dose of Generic for Rheumatrex : If your physician has instructed or directed you to take Generic for Rheumatrex medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and go back to your regular dosing schedule. Do not double the doses unless otherwise directed.
• Overdose of Generic for Rheumatrex : Any medication taken in excess can have serious consequences. If you suspect an overdose of Generic for Rheumatrex, seek medical attention immediately.

Side Effects

• Like other medicines, Generic for Rheumatrex can cause some side effects. If they do occur, the side effects of Generic for Rheumatrex are most likely to be minor and temporary. However, some may be serious and may require the individual to inform the doctor or visit the nearest hospital immediately.
• It is pertinent to note that side effects of Generic for Rheumatrex cannot be anticipated. If any side effects of Generic for Rheumatrex develop or change in intensity, the doctor should be informed as soon as possible.
• Generic for Rheumatrex can cause side effects such as nausea, vomiting, dizziness, headache, and blurred vision. This is not a complete list of all side effects. Do concur with your doctor and follow his directions completely when you are taking Generic for Rheumatrex.

Drug Interaction

• Usually drug interactions occur when it is taken with another drug or with food. Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications, over-the-counter medicines that may increase the effect of Generic for Rheumatrex, and dietary supplements like vitamins, minerals and herbal, so that the doctor can warn you of any possible drug interactions.
• Generic for Rheumatrex can interact with steroids and non-steroidal anti-inflammatory drugs.
• Also, tell your prescriber or health care professional if you are a frequent user of drinks containing caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

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Due to intra-patient variability, occasional individual haemoglobin values for a patient above and below the desired haemoglobin level may be observed. Haemoglobin variability should be addressed through dose management, with consideration for the haemoglobin target range of 10 g/dl (6.21 mmol/l) to 12 g/dl (7.45 mmol/l). A sustained haemoglobin level of greater than 12 g/dl (7.45 mmol/l) should be avoided; guidance for appropriate dose adjustment for when haemoglobin values exceeding 12 g/dl (7.45 mmol/l) are observed are described below.

A rise in haemoglobin of greater than 2 g/dl (1.24 mmol/l) over a four-week period should be avoided. If it occurs, appropriate dose adjustment should be made as provided.

Patients should be monitored closely to ensure that the lowest approved effective dose of MIRCERA is used to provide adequate control of the symptoms of anaemia whilst maintaining a haemoglobin concentration below or at 12 g/dl (7.45 mmol/l).

Caution should be exercised with escalation of MIRCERA doses in patients with chronic renal failure. In patients with a poor haemoglobin response to MIRCERA, alternative explanations for the poor response should be considered (see section 4.4 and 5.1).

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What are the possible side effects of Nexavar ?

• rash, blisters, oozing, or severe pain in the palms of your hands or the soles of your feet;
• increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);
• easy bruising, unusual bleeding;
• black, bloody, or tarry stools;
• coughing up blood or vomit that looks like coffee grounds;
• chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
• feeling short of breath, even with mild exertion;
• swelling, rapid weight gain;
• sudden numbness or weakness, especially on one side of the body; or
• confusion, loss of balance or coordination, or seizure (convulsions).

Less serious side effects may include:

• numbness, tingling, or swelling of your hands or feet;
• nausea, vomiting, constipation, diarrhea, stomach pain, loss of appetite;
• headache, tired feeling;
• tumor pain;
• pain in your joints, bones, or mouth;
• cough, trouble breathing;
• weight loss;
• hair loss; or
• dry, itchy skin.

What is the most important information:

• Nexavar can cause high blood pressure (hypertension). Before using this medication, tell your doctor if you have a history of hypertension. Your blood pressure will need to be checked on a regular basis while you are using Nexavar.
• Call your doctor at once if you have serious side effects such as rash, blisters, oozing, or severe pain in the palms of your hands or the soles of your feet; unusual bruising or bleeding; chest pain spreading to the arm or shoulder; feeling short of breath; or sudden numbness or weakness.
• Using Nexavar while you are pregnant can cause harm to the unborn baby. Do not use this medication if you are pregnant. Tell your doctor if you become pregnant during treatment. Both men and women taking Nexavar should use an effective form of birth control while taking the medication and for at least 2 weeks after treatment ends.

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Additional Information:

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• Prostate cancer

• Diabetes
• Disease involving the heart and blood vessels (cardiovascular disease)
• Disease of the blood vessels in and around the brain (cerebrovascular disease)
• Disorders that increase the risk of blood clots in the blood vessels (thromboembolic disorders)
• High blood pressure (hypertension)
• Liver disease
• People over the age of 75 years

• Known sensitivity or allergy to any ingredient
• This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
  
  If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
• Pregnancy and Breastfeeding
• Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
• This medicine should not be used during pregnancy as it may be harmful to the unborn baby. Seek medical advice from your doctor.
• There is no information available regarding the safety of this medicine during breastfeeding. Seek medical advice from your doctor.

• Abdominal cramps
• Impotence
• Skin rashes
• Visual disturbances
• Yellowing of the skin and eyes (jaundice)
• Abnormal enlargement of breasts in men (gynaecomastia)
• Fever (pyrexia)
• Retention of water in the body tissues (fluid retention)
• High blood calcium level (hypercalcaemia)
• Dizziness
• Bone pain
• Loss of appetite
• Blood clots in the blood vessels (thrombosis) that may detach and travel in the circulation to another area of the body (thromboembolism)
• Nausea and vomiting

FOB:241.2

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• ImmunoRelis a solvent detergent treated, chromatographically purified immunoglobulin G(IgG) derived from pooled human plasma.
• The approved indications include Primary Immunodeficiency (PID), Kawasaki disease, Idiopathic Thrombocytopenic Purpura, B-cell Chronic lymphocytic leukaemia, Paediatric HIV 1 infection and Hemopoietic stem cell transplantation in elderly.
• The clinical experience has also shown efficacy in GB syndrome, Multifocal Motor Neuropathy, CIDP, Lambert Eaton Myasthenic syndrome, Myasthenia Gravis, Neonatal Sepsis, Polymyositis, Dermatomyositis and few others.
• The normal immunoglobulin is meant for intravenous use.

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